The hemostatic system as a modulator of atherosclerosis.
نویسنده
چکیده
n engl j med 365;3 nejm.org july 21, 2011 278 do not observe, in an underpowered study, a pattern of mutual exclusivity between NFKBIA deletion and EGFR amplification when analyzing together grades II, III, and IV gliomas, nor do they find a relationship between survival and having a tumor that bears an NFKBIA deletion. Since the publication of our report, we have gone on to test these associations with the use of extended data from the Cancer Genome Atlas (TCGA) project. Using gene copy-number data generated by two independent TCGA Genome Characterization Centers on different genotyping platforms, we again observed a pattern of relative mutual exclusivity between deletion of NFKBIA and amplification of EGFR in glioblastomas (P = 2×10−3 by Pearson’s chisquare test; odds ratio for concomitant deletion and amplification, 0.46; 95% confidence interval [CI], 0.29 to 0.74) (Fig. 1A in the Supplementary Appendix, available with the full text of this letter at NEJM.org). We also again observed that patients with tumors with the NFKBIA deletion had poorer outcomes than did those who had glioblastomas with normal gene dosages of NFKBIA and EGFR (hazard ratio for death with the NFKBIA deletion, as compared with normal dosages of both NFKBIA and EGFR, 1.41; 95% CI, 1.02 to 1.94; P = 0.039 by the Cox model), and had outcomes similar to those with tumors harboring EGFR amplification (hazard ratio for death with isolated NFKBIA deletion, as compared with isolated EGFR amplification, 0.93; 95% CI, 0.68 to 1.29; P = 0.68 by the Cox model) (Fig. 1B in the Supplementary Appendix). The estimated median survival times were 47 weeks for patients whose tumors harbored an isolated NFKBIA deletion, 53 weeks for those whose tumors had isolated EGFR amplification, and 67 weeks for those whose tumors had normal dosages of both NFKBIA and EGFR.
منابع مشابه
Preliminary Design of Spacecraft Attitude Control with Pulse-Width Pulse-Frequency Modulator for Rest-to-Rest Maneuvers
In this paper, the preferred region of design parameters for quasi-normalized equations of single-axis attitude control of rigid spacecraft using pulse-width pulse-frequency modulator (PWPFM) is presented for rest-to-rest maneuvers. Using the quasi-normalized equations for attitude control reduces the system parameters, that is, the moment of inertia, the filter gain, and the maximum torque of ...
متن کاملPerformance Scrutiny of Two Control Schemes Based on DSM and HB in Active Power Filter
This paper presents a comparative analysis between two current control strategies, constant source power and generalized Fryze current, used in Active Power Filter (APF) applications having three different modulation methods. The Hysteresis Band (HB) and first-order Delta-Sigma Modulation (DSM) as well as the second-order DSM is applied. The power section of the active power filter is viewed as...
متن کاملطراحی و ساخت مدولاتور لامپ تترود جهت شتاب‌دهنده پرقدرت الکترون
In this paper, a high power tetrode tube (TH781-200kW, cw) modulator is designed and implemented. This modulator is used for a part of RF system of the first Iranian high power electron accelerator project with similar structure to Rhodotron accelerator. Regarding to the level of sensitive and importance of TH781 tube the modulator system designed with high accuracy. So beside of power suppli...
متن کاملQuadrature delta sigma modular design with adjustable bandwidth and center frequency
In this paper, a flexible Continuous time (CT) feedforward (FF) quadrature delta sigma modulator (QDSM) with variable bandwidth (BW) is proposed. The modulator BW and center frequency (fc) are variable which can be adjusted with two separate parameters. The modulator signal-to-noise ratio (SNR) will be optimized by these parameters at every center frequency and bandwidth. The modulator BW is ch...
متن کاملScreening the Hemostatic Active Fraction of Artemisia annua L. In-vitro
Artemisinin extracted from Artemisia annua L. is the best medicine with the highest efficiency, the most effective and the lowest toxicity in treating ague nowadays. At present, most studies focus on artemisinin and its derivatives, while the study and report about the other active components are rare. This paper purposed to further discover new indication of Artemisia annua L. connecting with ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The New England journal of medicine
دوره 365 3 شماره
صفحات -
تاریخ انتشار 2011